| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372526 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
CB1 receptor antagonists that are peripherally restricted were targeted. Compounds with permanent charge as well as compounds that have increased polar surface area were made and tested against CB1 for binding and activity. Sulfonamide and sulfamide with high polar surface area and good activity at CB1 were rationally designed and pharmacologically tested. Further optimization of these compounds and testing could lead to the development of a new class of therapeutics to treat disorders where the CB1 receptor system has been implicated.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Alan Fulp, Katherine Bortoff, Yanan Zhang, Herbert Seltzman, Rodney Snyder, Rangan Maitra,