Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372527 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Two new phenylpyridines, named coprismycins A and B (1 and 2), and previously reported dipyridines (3–6) were isolated from a culture of Streptomyces sp. associated with the dung beetle, Copris tripartitus. The structures of the coprismycins (1 and 2) were elucidated by the analysis of 1D and 2D NMR spectra and mass, UV, and IR spectra. Coprismycins A-B (1 and 2) and dipyridines (5 and 6) displayed comparable neuroprotective effects against MPP+ (1-methyl-4-phenylpyrimidium)-induced neurotoxicity in neuroblastoma SH-SY5Y cells.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Seong-Hwan Kim, Hyeonseok Ko, Hea-Son Bang, Seon-Hui Park, Dong-Gyu Kim, Hak Cheol Kwon, Sun Yeou Kim, Jongheon Shin, Dong-Chan Oh,