| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372529 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
5-Isoproyl-3,8-dimethylazulene derivatives were synthesized and evaluated for antigastric ulcer activity in vivo. Some of them possess the best activity against gastric ulcer with ulcer index values lower than the drug reference (omeprazole). The structure–activity relationship (SAR) shows that the lipophilic flat structure contributes to quite potent antigastric ulcer activity.
Graphical abstractN-[4-(2-Thienylmethyleneamino)phenyl]-5-isopropyl-3,8-dimethylazulene-1-sulfonamide (6c). Molecular formula: C26H26N2O2S2.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lu-Yun Zhang, Fang Yang, Wan-Qi Shi, Ping Zhang, Ying Li, Shu-Fan Yin,