Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372534 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated γ-lactone fragment. It was revealed that the number of fluorine atoms on the γ-lactone moiety affects the growth inhibitory activities against human cancer cell lines.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Naoto Kojima, Yuki Suga, Hiromi Hayashi, Takao Yamori, Takehiko Yoshimitsu, Tetsuaki Tanaka,