Article ID Journal Published Year Pages File Type
1372537 Bioorganic & Medicinal Chemistry Letters 2011 5 Pages PDF
Abstract

Radionuclide chelators (DOTA, NOTA) functionalized with a monofluorocyclooctyne group were prepared. These materials reacted rapidly and in high yield with a fully deprotected azide-modified peptide via Cu-free click chemistry under mild reaction conditions (aqueous solution, room temperature). The resulting bioconjugates bind with high affinity and specificity to their cell-surface receptor targets in vitro and appear stable to degradation in mouse serum over 3 h of incubation at 37 °C.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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