| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372552 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of novel ethyl 5-(4-aminophenyl)-1H-pyrazole-3-carboxylate derivatives were designed and synthesized and their in vitro acrosin inhibitory activities were evaluated. Most of the compounds exhibited acrosin inhibitory activities. Among them, three compounds (5l, 5n, and 5v) were more potent than that of the control TLCK. These provide a new structural type for the development of novel contraceptive acrosin inhibitory agents.
Graphical abstractA novel series of substituted ethyl 5-(4-aminophenyl)-1H-pyrazole-3-carboxylate derivatives were designed, synthesized and biologically evaluated as acrosin inhibitors.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jingjing Qi, Ju Zhu, Xuefei Liu, Lili Ding, Canhui Zheng, Guangqian Han, Jiaguo Lv, Youjun Zhou,