| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372557 | Bioorganic & Medicinal Chemistry Letters | 2011 | 7 Pages |
Abstract
A structure–activity relationship (SAR) study was carried out to identify novel, small molecular weight compounds which induce readthrough of premature termination codons. In particular, analogs of RTC13, 1, were evaluated. In addition, hypothesizing that these compounds exhibit their activity by binding to the ribosome, we prepared the hybrid analogs 13 containing pyrimidine bases and these also showed good readthrough activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michael E. Jung, Jin-Mo Ku, Liutao Du, Hailiang Hu, Richard A. Gatti,