Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372563 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
A series of substituted imidazo[1,2-a]pyrazin-8-amines were discovered as novel breast tumor kinase (Brk)/protein tyrosine kinase 6 (PTK6) inhibitors. Tool compounds with low-nanomolar Brk inhibition activity, high selectivity towards other kinases and desirable DMPK properties were achieved to enable the exploration of Brk as an oncology target.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hongbo Zeng, David B. Belanger, Patrick J. Curran, Gerald W. Shipps Jr., Hua Miao, Jack B. Bracken, M. Arshad Siddiqui, Michael Malkowski, Yan Wang,