| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372563 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
A series of substituted imidazo[1,2-a]pyrazin-8-amines were discovered as novel breast tumor kinase (Brk)/protein tyrosine kinase 6 (PTK6) inhibitors. Tool compounds with low-nanomolar Brk inhibition activity, high selectivity towards other kinases and desirable DMPK properties were achieved to enable the exploration of Brk as an oncology target.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Hongbo Zeng, David B. Belanger, Patrick J. Curran, Gerald W. Shipps Jr., Hua Miao, Jack B. Bracken, M. Arshad Siddiqui, Michael Malkowski, Yan Wang,