Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372568 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of 3,5-bis(indolyl)-1,2,4-thiadiazoles were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. The reaction of indole-3-thiocarboxamide 3 with iodobenzene diacetate underwent oxidative dimerization to give 3,5-bis(indolyl)-1,2,4-thiadiazoles 4a–n. Among the synthesized bis(indoly)-1,2,4-thiadiazoles, the compound 4h with 4-chlorobenzyl and methoxy substituents showed the most potent activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dalip Kumar, N. Maruthi Kumar, Kuei-Hua Chang, Ritika Gupta, Kavita Shah,