Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372573 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
We report, for the first time, that certain N-acetylthiourea derivatives serve as highly potent and isozyme selective activators for the recombinant form of human histone deacetylase-8 in the assay system containing Fluor-de-Lys as a fluorescent substrate. The experimental data reveals that such activating feature is manifested via decrease in the Km value of the enzyme’s substrate and increase in the catalytic turnover rate of the enzyme.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Raushan K. Singh, Tanmay Mandal, Narayanaganesh Balsubramanian, Tajae Viaene, Travis Leedahl, Nitesh Sule, Gregory Cook, D.K. Srivastava,