| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372579 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
The synthesis, GSK-3β inhibitory activity, and anti-microbial activity of bicyclic and tricyclic derivatives of the 5,7-diamino-6-fluoro-4-quinolone-3-carboxylic acid scaffold were studied. Kinase selectivity profiling indicated that members of this class were potent and highly selective GSK-3 inhibitors.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Oana M. Cociorva, Bei Li, Tyzoon Nomanbhoy, Qiang Li, Ayako Nakamura, Kai Nakamura, Masahiro Nomura, Kyoko Okada, Shigeki Seto, Kazuhiro Yumoto, Marek Liyanage, Melissa C. Zhang, Arwin Aban, Brandon Leen, Anna Katrin Szardenings, Jonathan S. Rosenblum,