Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372586 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
We previously reported that phenanthroindolizidine alkaloid 3 and its derivatives had markedly potent in vitro cytotoxicity. However, they had low in vivo antitumor activities and high in vivo toxicities, which was a serious problem. To address this problem, new phenanthroindolizidine derivatives were synthesized and their antitumor activities and toxicities were evaluated. This study describes the relationship between the chemical structures, antitumor activities, and toxicities of these phenanthroindolizidine derivatives. Based on its properties, compound 8 was found to be the most suitable potential antitumor agent.
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Authors
Takashi Ikeda, Takashi Yaegashi, Takeshi Matsuzaki, Ryuta Yamazaki, Syusuke Hashimoto, Seigo Sawada,