| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372602 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Based on antiviral screening of our diphenylmethane derivatives prepared as steroid substitutes, we identified a 1,1-diphenylcyclobutane analog (9) and two diethyldiphenylsilane analogs (12 and 13) as superior lead compounds with potent anti-bovine viral diarrhea virus (BVDV) activity, having 50% effective concentration (EC50: based on reduction of BVDV replication-induced cell destruction) and 50% cytotoxic concentration (CC50: based on reduction of viable cell number) values of 6.2–8.4 μM and >100 μM, respectively, in Madin–Darby bovine kidney (MDBK) cells infected with BVDV.
Graphical abstract1,1-Diphenylcyclobutane analog and diethyldiphenylsilane analogs have been identified as superior lead compounds with potent anti-bovine viral diarrhea activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
