Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372629 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
This Letter describes the discovery of a novel series of mGluR5 positive allosteric modulators (PAMs). The lead compound, 11c, exhibits excellent potency (EC50 = 30 nM) in vitro, and reaches high brain levels in both rats and mice after oral administration.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andreas Ritzén, Rikke Sindet, Morten Hentzer, Nannette Svendsen, Robbin M. Brodbeck, Christoffer Bundgaard,