Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372630 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A cyclic decapeptide was chemically synthesized that mimics the loop structure of a β-hairpin arm of the EGF receptor, which is highly involved in receptor dimerization upon activation by ligand binding. This peptide was revealed to reduce dimer formation of the receptor in a detergent-solubilized extract of epidermoid carcinoma A431 cells and to inhibit receptor autophosphorylation at less than 10 μM in the intact cells.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takaaki Mizuguchi, Hiromasa Uchimura, Taeko Kakizawa, Tooru Kimura, Shigeyuki Yokoyama, Yoshiaki Kiso, Kazuki Saito,