| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372638 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Oligonucleotides including C-nucleotides having 1-substitued 1H-1,2,3-triazoles as artificial nucleobases were conveniently synthesized by the post-elongation modification method using the copper(I)-catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC) reaction. The base-pairing properties of the triazole nucleobase analogs in forming duplexes with oligonucleotides were investigated by the Tm experiments.
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Authors
Motoi Nakahara, Takeshi Kuboyama, Akihiro Izawa, Yoshiyuki Hari, Takeshi Imanishi, Satoshi Obika,