| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372641 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
The design and profile of a series of zwitterionic calcium sensing receptor negative allosteric modulators is described. Evaluation of key analogues using a rat model demonstrate a robust response, significantly improved potency over ronacaleret and have the potential as an oral, anabolic treatment for osteoporosis.
Graphical abstractThe discovery of a structurally novel, orally bioavailable series of calcium sensing receptor negative allosteric modulators is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gayatri Balan, Jonathan Bauman, Samit Bhattacharya, Mayda Castrodad, David R. Healy, Michael Herr, Paul Humphries, Sandra Jennings, Amit S. Kalgutkar, Brendon Kapinos, Vishal Khot, Kimberly Lazarra, Mei Li, Yan Li, Constantin Neagu, Robert Oliver,