| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372659 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Two new (−)-muricatacin mimics bearing a furano-furanone ring and an oxygen isostere in the side chain have been designed and synthesized and their in vitro antiproliferative activity was evaluated against several human tumour cell lines. Both analogues showed an increased activity against HL-60 cells with 17- and 185-fold higher potency than (−)-muricatacin. A straightforward synthesis of (−)-muricatacin is also disclosed.
Graphical abstract(−)-Muricatacin (1) and the related mimics 3 and 4 have been synthesized and evaluated for their in vitro antitumour activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Velimir Popsavin, Bojana Srećo, Goran Benedeković, Mirjana Popsavin, Jovana Francuz, Vesna Kojić, Gordana Bogdanović,