| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372677 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A novel series of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor is reported. Starting from a 3.4 μM high throughput screen hit, members of this series have been identified which are full agonists with functional potency <50 nM and oral bioavailability in mice.
Graphical abstractA novel series of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor is reported. Members of this series have been identified which are full agonists with functional potency <50 nM and oral bioavailability in mice.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Phil B. Alper, Thomas H. Marsilje, Daniel Mutnick, Wenshuo Lu, Arnab Chatterjee, Michael J. Roberts, Yun He, Donald S. Karanewsky, Donald Chow, Jianmin Lao, Andrea Gerken, Tove Tuntland, Bo Liu, Jonathan Chang, Perry Gordon, H. Martin Seidel,