Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372686 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A high-throughput screening campaign identified a number of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7. Further synthetic chemistry efforts enabled the preparation of a number of analogues with promising in vitro potencies. Although these compounds show likely broad spectrum inhibitory activity, they represent a useful starting point for further chemical optimisation.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nathalie Bouloc, Jonathan M. Large, Ela Smiljanic, David Whalley, Keith H. Ansell, Christopher D. Edlin, Justin S. Bryans,