| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372700 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
The same two major CYP mediated metabolites of DG-051 were produced in the presence of rat, dog, monkey and human liver microsomes. Their respective structures were hypothesized based on mass spectrometry data correlated with the parent structure and confirmed by comparison with authentic synthetic samples. The number of regioisomers synthesized as candidates for metabolite M1 was narrowed down using a metabolic study of a selectively deuterated DG-051 analogue.
Graphical abstractThe identification and synthesis of two CYP mediated metabolites of DG-051 are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Livia A. Enache, Jun Zhang, David W. Sullins, Isaac Kennedy, Emmanuel Onua, David E. Zembower, Frank W. Muellner, Jasbir Singh, Alex S. Kiselyov,