Ionic liquid mediated and promoted eco-friendly preparation of thiazolidinone and pyrimidine nucleoside–thiazolidinone hybrids and their antiparasitic activities

Without any catalyst, 2,3-disubstituted-1,3-thiazolidin-4-one derivatives were synthesized efficiently via the three-component reaction of aldehyde, amine and mercaptoacetic acid in [bmim][PF6]. The whole procedure is simple and straightforward and no aqueous work-up is needed. By employing this protocol, a series of novel pyrimidine nucleoside–thiazolidin-4-one hybrids were prepared and their preliminary antiparasitic activities were also studied and reported.

Graphical abstractNovel pyrimidine nucleoside–thiazolidinone hybrids with antiparasitic activities were synthesized via an eco-friendly and efficient three-component reaction in [bmim][PF6].Figure optionsDownload full-size imageDownload as PowerPoint slide