| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372703 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Tetrahydroneotanshinlactone (TNT) and tetrahydronaphthalene-1-ol (TNO) derivatives were designed, synthesized, and evaluated for cytotoxic activity. The TNO derivatives were found to be a promising novel class of in vitro antitumor agents. The cyclohexene ring-A could dramatically affect the antitumor activity and selectivity. Compound 20 showed the highest potency with ED50 values of 0.7 and 1.7 μM against SK-BR-3 and ZR-75-1 breast cancer cell lines, respectively.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yizhou Dong, Qian Shi, Kyoko Nakagawa-Goto, Pei-Chi Wu, Kenneth F. Bastow, Susan L. Morris-Natschke, Kuo-Hsiung Lee,