Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin

Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay.

Graphical abstractNovel amide derivatives of non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity and the deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity.Figure optionsDownload full-size imageDownload as PowerPoint slide