Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis

A series of sugar derivatives (1–13) were synthesized and evaluated for antibacterial activity against Mycobacteriumtuberculosis (MTB), especially multi-drug resistant (MDR) MTB, and the structure–activity relationships of these compounds were studied. The results showed that the compound OCT313 (2-acetamido-2deoxy-β-d-glucopyranosyl N,N-dimethyldithiocarbamate) (4) exhibited significant in vitro bactericidal activity, and that the dithiocarbamate group at C-1 position of the glucopyranoside ring was requisite for the antibacterial activity.

Graphical abstractThe anti-mycobacterial properties of sugar derivatives synthesized and evaluated for antibacterial activity against Mycobacteriumtuberculosis (MTB), especially multi-drug resistant (MDR) MTB 4 (MIC = 1.56–25 μg/ml) is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide