| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372715 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of dialkylphosphocholines were prepared and evaluated for their biological activity. The antiprotozoal activity was determined against Acanthamoeba lugdunensis. Compound 15 exhibited excellent trophocidal activity. None of the tested dialkylphosphocholines exhibited better fungicidal activity against Candida albicans than miltefosine. The antineoplastic activity was determined against HeLa. The most cytotoxic was compound 10, which was more active against tumor cells as against normal cells.
Graphical abstractThe synthesis and antiprotozoal, antimycotic, and cytotoxic activity of dialkylphosphocholines are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Miloš Lukáč, Martin Mrva, Eva Fischer-Fodor, Ivan Lacko, Marián Bukovský, Natalia Miklášová, František Ondriska, Ferdinand Devínsky,