| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372729 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Synthesis of several novel imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV are described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity and pharmacokinetics are highlighted. Several compounds with low nanomolar anti-HIV activity and oral bioavailability are described.
Graphical abstractSynthesis of several novel imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1 are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kristjan S. Gudmundsson, Sharon D. Boggs, John G. Catalano, Angilique Svolto, Andrew Spaltenstein, Michael Thomson, Pat Wheelan, Stephen Jenkinson,