| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372731 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
Based on tetrapeptide AVPI, we were able to design and synthesize a new simplified scaffold to inhibit the BIR3 domain of the XIAP protein at low micromolar range. The uncomplicated synthesis and the binding activity of the molecule disclosed here represent an attractive alternative to develop new compounds targeting the protein–protein interaction of XIAP/caspase9.
Graphical abstractBased on tetrapeptide AVPI we were able to design and synthesize a new simplified scaffold to inhibit the BIR3 domain of the XIAP protein at low micromolar range.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Fernando R. Pinacho Crisóstomo, Yongmei Feng, Xuejun Zhu, Kate Welsh, Jing An, John C. Reed, Ziwei Huang,