Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372736 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of novel pyrrolopyridazine derivatives have been discovered to be HER-2 inhibitors. These compounds selectively inhibited HER-2 kinase activity at low nanomolar concentrations. Compound 7d was identified as a potent HER-2 inhibitor with an IC50 of 4 nM.
Graphical abstractA series of novel pyrrolopyridazine derivatives have been discovered to be HER-2 inhibitors. These compounds selectively inhibited HER-2 kinase activity at low nanomolar concentrations. Compound 7d was identified as a potent HER-2 inhibitor with an IC50 of 4 nM.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Peng Cho Tang, Jun Feng, Li Huang, Zhe Xu, Ling Cheng, Xu Zhang, Lei Zhang, Bing Hu,