| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372740 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
The syntheses of 2-methoxyestradiol analogs with modifications at the 3-position are described. The analogs were assessed for their antiproliferative, antiangiogenic, and estrogenic activities. Several lead substituents were identified with similar or improved antitumor activities and reduced metabolic liability compared to 2-methoxyestradiol.
Graphical abstractA lead-generation series of analogs of 2-methoxyestradiol modified at the 3-position were designed, synthesized and evaluated for antiproliferative, antiangiogenic, and estrogenic properties.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lita S. Suwandi, Gregory E. Agoston, Jamshed H. Shah, Arthur D. Hanson, Xiaoguo H. Zhan, Theresa M. LaVallee, Anthony M. Treston,