Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372744 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
The solid-phase synthesis of a library based on an unusual biphenyl-containing trypsin-like serine protease inhibitor is described. Key to this effort was the synthesis of a highly functionalized aryl boronic acid reagent which required the development of a novel and efficient method to convert a triflate to a pinacolboronate in large scale.
Graphical abstractA novel and efficient method for synthesizing a highly functionalized aryl boronic acid reagent in large scale was developed. A hug biphenyl scaffold library for trypsin-like serine protease inhibitor by solid-phase synthesis is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shuhao Shi, Shirong Zhu, Samuel W. Gerritz, Bogumila Rachwal, Zheming Ruan, Robert Hutchins, Ramesh Kakarla, Michael J. Sofia, James Sutton, Daniel Cheney,