| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372753 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Extracellular heat shock proteins (eHsps) in blood circulation have been associated with various diseases, including cancer. However, the lack of methods to enrich eHsps from serum samples has hampered the characterization of eHsps. This Letter presents our serendipitous finding that the monomeric avidin resin can serve as an affinity resin to enrich eHsps from blood serum. Biochemical mechanism of this eHsp enrichment as well as implications in biomarker discovery is discussed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Doina M. Mihai, Haiteng Deng, Akira Kawamura,