| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372755 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
A series of inhibitors of mammalian 15-lipoxygenase (15-LO) based on a 3,4,5-tri-substituted pyrazole scaffold is described. Replacement of a sulfonamide functionality in the lead series with a sulfamide group resulted in improved physicochemical properties generating analogs with enhanced inhibition in cell-based and whole blood assays.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Khehyong Ngu, David S. Weinstein, Wen Liu, Charles Langevine, Donald W. Combs, Shaobin Zhuang, Xing Chen, Cort S. Madsen, Timothy W. Harper, Saleem Ahmad, Jeffrey A. Robl,