Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372756 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of pyridyl amide/sulfonamide inhibitors of 11β-HSD-1 were modified to incorporate a novel 1,2,4-triazolopyridine scaffold. Optimization of substituents at the 3 and 8 position of the TZP core, with a special focus on enhancing metabolic stability, resulted in the identification of compound 38 as a potent and metabolically stable inhibitor of the enzyme.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Haixia Wang, Jeffrey A. Robl, Lawrence G. Hamann, Ligaya Simpkins, Rajasree Golla, Yi-Xin Li, Ramakrishna Seethala, Tatyana Zvyaga, David A. Gordon, James J. Li,