| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372771 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Directed screening has identified a novel series of MMP13 inhibitors that possess good levels of activity whilst possessing excellent selectivity over related MMPs. The binding mode of the series has been solved by co-crystallisation and demonstrates an interesting mode of inhibition without interaction with the catalytic zinc atom.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chris De Savi, Andrew D. Morley, Attilla Ting, Ian Nash, Kostas Karabelas, Christine M. Wood, Michael James, Stephen J. Norris, Galith Karoutchi, Neil Rankine, Gordon Hamlin, Philip A. MacFaul, David Ryan, Sarah V. Baker, David Hargreaves,