Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372774 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Inducible arginine oxidation and subsequent NO production by correspondent synthase (iNOS) are important cellular answers to proinflammatory signals. Prolonged NO production has been proved in higher organisms to cause stroke or septic shock. Several classes of potent NOS inhibitors have been reported, most of them targeting the arginine binding site of the oxygenase domain. Here we disclose the SAR and the rational design of potent and selective iNOS inhibitors which may be useful as anti-inflammatory drugs.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ulrich Grädler, Thomas Fuchß, Wolf-Rüdiger Ulrich, Rainer Boer, Andreas Strub, Christian Hesslinger, Céline Anézo, Kay Diederichs, Andrea Zaliani,