Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372778 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
As a model compound for the transcription factor hijacking mechanism of action of DNA damaging agent that simultaneously bind to the nuclear receptor, we designed and synthesized a chimeric molecule, RA-mustard, which can bind with both retinoic acid receptor α (RARα) and DNA. The interaction between RA-mustard with RARα was confirmed by binding assay using RARα-overexpressing cell extract. RA-mustard-modified DNA diminished the RARα-dependent luciferase expression in the RARα-abundant cells.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kyung Hoon Min, Byoung-Gu Yun, Yoonsung Lee, Jiho Song, Won-Hoon Ham, YoungJoo Lee, Hyun-Ju Park,