Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372784 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Coxsackievirus and related enteroviruses are important human pathogens that cause various diseases with clinical manifestations ranging from trivial flu-like syndromes to dangerous or even fatal diseases such as myocarditis, meningitis and encephalitis. Here, we report on our continuous SAR study focused on 9-(bicyclo[2.2.1]hept-2-yl)-9H-purines as anti-enteroviral inhibitors. The purine moiety was modified at positions 2, 6 and 8. Several analogues inhibited Coxsackievirus B3 as well as other enteroviruses at low-micromolar concentrations. The 6-chloropurine derivative was confirmed as the most active compound in this series.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michal Šála, Armando M. De Palma, Hubert Hřebabecký, Milan Dejmek, Martin Dračínský, Pieter Leyssen, Johan Neyts, Helena Mertlíková-Kaiserová, Radim Nencka,