| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372789 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of new muramyl dipeptide (MDP) mimics were designed and synthesized via a solid-phase synthetic route. Their adjuvant activities were evaluated ex vivo for investigation of the synergism of the S28–39 peptide, which is an MHC class I binding epitope of recombinant hepatitis B surface antigen (HBsAg) for both humans and mice. Several compounds without the carbohydrate moiety exerted better adjuvanticity than the MDP-C that has been reported by our laboratory previously. A primary screening test revealed that compounds 6, 14 and 16 exhibited stronger adjuvanticity compared with other MDP mimics.
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Related Topics
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Authors
Nan Zhao, Yao Ma, Shengmei Zhang, Xin Fang, Zhenglun Liang, Gang Liu,