Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372800 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
We describe the discovery and optimization of a novel series of benzofuran EP1 antagonists, leading to the identification of 26d, a novel nonacidic EP1 antagonist which demonstrated efficacy in preclinical models of chronic inflammatory pain.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Amanda C. Allan, Andy Billinton, Susan H. Brown, Anita Chowdhury, Andrew J. Eatherton, Charlotte Fieldhouse, Gerard M.P. Giblin, Paul Goldsmith, Adrian Hall, David N. Hurst, Alan Naylor, D. Anthony Rawlings, Mairi Sime, Tiziana Scoccitti,