Synthesis and activities of naphthalimide azoles as a new type of antibacterial and antifungal agents

Naphthalimide-derived azoles as a new type of antimicrobial agents were synthesized and evaluated for their efficiency in vitro against eight bacteria and two fungi by two fold serial dilution technique. Most title compounds exhibited good antimicrobial potency with low MIC values ranging from 1 to 16 μg/mL. Notably, some synthesized compounds displayed comparable or even better antibacterial and antifungal activities against some tested strains than the reference drugs Orbifloxacin, Chloromycin and Fluconazole, respectively.

Graphical abstractNovel naphthalimide-derived azoles were synthesized and evaluated for antimicrobial activities. Most of the tested compounds exhibited good antimicrobial activities with low MIC values ranging from 1 to 16 μg/mL.Figure optionsDownload full-size imageDownload as PowerPoint slide