| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372811 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
We report the development of aryl sulfones as Bradykinin B1 receptor antagonists. Variation of the linker region identified diol 23 as a potent B1 antagonist, while modifications of the aryl moiety led to compound 26, both of which were efficacious in rabbit biochemical challenge and pain models.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kaustav Biswas, Toshihiro Aya, Wenyuan Qian, Tanya A.N. Peterkin, Jian Jeffrey Chen, Jason Human, Randall W. Hungate, Gondi Kumar, Leyla Arik, Dianna Lester-Zeiner, Gloria Biddlecome, Barton H. Manning, Hong Sun, Hong Dong, Ming Huang, Richard Loeloff,