| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372817 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A hybrid compound (DO3A-BP) featuring a radiometal bifunctional chelator (1,4,7,10-tetraazacyclotetradecane-N,N′,N″,N‴-tetraacetic acid, DOTA) and an osteoclast-targeting moiety (bisphosphonate) was designed and synthesized. The 111In-labeled complex of DO3A-BP showed significantly elevated uptake in osteoclasts compared to the undifferentiated adherent bone marrow derived cells. Biodistribution studies revealed a favorable tissue distribution profile in normal mice with high bone uptake and long retention, and low or negligible accumulation in non-target organs.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Wei Liu, Asghar Hajibeigi, Mai Lin, Cynthia L. Rostollan, Zoltan Kovacs, Orhan K. Öz, Xiankai Sun,