Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372822 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Baeyer–Villiger oxidation of 5-aryl-7,11,11-trimethyltricyclo[5.4.0.03,6]-undec-1-en-4-ones 4a–h by H2O2 and formic acid in methanol yields mixtures of 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro-1H-indeno-[1,2-c]furan-1-ones 8a–h and 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro-1H-indeno-[1,2-c]furan-2-ones 9a–h in high yields. The obtained butyrolactones 8a–h display cytotoxic activity against a number of human cancer cells.
Graphical abstractSome of the lactones display valuable cytotoxic activity against cancer cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
M.P.S. Ishar, Tilak Raj, Satyam Kumar Agrawal, A.K. Saxena, Lakhwinder Singh, Rajinder Singh, Surinderjit Singh Bhella,