Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372824 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
A series of piperazinebenzylalcohols were prepared and studied to compare with their ketone and amine analogs as MC4R antagonists. Several benzylalcohols such as 14a and 14g displayed low nanomolar binding affinities (Ki < 10 nM), and high selectivities over other melanocortin receptor subtypes.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dragan Marinkovic, Fabio C. Tucci, Joe A. Tran, Beth A. Fleck, Jenny Wen, Chen Chen,