| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372828 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
A series of thiadiazolopiperazinyl aryl urea fatty acid amide hydrolase (FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR and PK properties are presented.
Graphical abstractA series of thiadiazolopiperazinyl aryl urea fatty acid amide hydrolase (FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR and PK properties are presented.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
John M. Keith, Richard Apodaca, Wei Xiao, Mark Seierstad, Kanaka Pattabiraman, Jiejun Wu, Michael Webb, Mark J. Karbarz, Sean Brown, Sandy Wilson, Brian Scott, Chui-Se Tham, Lin Luo, James Palmer, Michelle Wennerholm, Sandra Chaplan,