Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372829 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
A novel class of potent and selective inhibitors of KDR incorporating an indazole moiety 1 is reported. The discovery, synthesis, and structure–activity relationships of this series of inhibitors have been investigated. The most promising compounds were also profiled to determine their pharmacokinetic properties and evaluated in a VEGF-induced vascular permeability assay.
Graphical abstractA novel class of potent and selective inhibitors of KDR incorporating an indazole moiety 1 is reported. The discovery, synthesis, and structure–activity relationships of this series of inhibitors have been investigated. The most promising compounds were also profiled to determine their pharmacokinetic properties and evaluated in a VEGF-induced vascular permeability assay.Figure optionsDownload full-size imageDownload as PowerPoint slide