Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372836 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
We have prepared a novel speculative eight-membered lactam demonstration library based on the skeletal structure of the potent antitumor marine natural product octalactin A. The basic scaffold was readily constructed in a convergent fashion via ring-closing metathesis chemistry from the corresponding diene amides. A cursory examination of the biological properties of the library validates the relevance and significance of these structures.
Graphical abstractWe have prepared a novel speculative eight-membered lactam demonstration library inspired by the antitumor natural product octalactin A. The basic scaffold was readily constructed in a convergent fashion via RCM from the corresponding diene amides. A cursory examination of the biological properties of the library validates the relevance and significance of these structures.Figure optionsDownload full-size imageDownload as PowerPoint slide