| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372838 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
The synthesis and biological evaluation of libraries of 8-biarylchromen-4-ones enabled the elucidation of structure-activity relationships for inhibition of the DNA-dependent protein kinase (DNA-PK), with 8-(3-(thiophen-2-yl)phenyl)chromen-4-one and 8-(3-(thiophen-3-yl)phenyl)chromen-4-one being especially potent inhibitors.
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Marine Desage-El Murr, Celine Cano, Bernard T. Golding, Ian R. Hardcastle, Marc Hummersome, Mark Frigerio, Nicola J. Curtin, Keith Menear, Caroline Richardson, Graeme C.M. Smith, Roger J. Griffin,