Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372878 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
P-glycoprotein (P-gp) is an important factor in the development of multidrug resistance (MDR) in cancer cells. In literature reports, a thieno[2,3-d]pyrimidine (QB13) was described as P-gp modulator and opposed effects on the cell accumulation of distinct P-gp substrates were postulated. On the basis of this lead structure, a series of 2-alkylthio-4-aminothieno[2,3-d]pyrimidines was prepared and tested in a daunorubicin accumulation assay. Modulation of substrate specificity was shown for selected compounds in cytotoxicity (MTT) assays.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hans-Georg Häcker, Antje de la Haye, Katja Sterz, Gregor Schnakenburg, Michael Wiese, Michael Gütschow,